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I'm trying to use the simbiology app to fit data with a simbiology model. The problem is that between the data groups there is a independent variable (AHL) that changes between them (image 1). When the data was imported I defined the AHL row as a covariate (which I think is right) as seen in the image 1. The problem is that when I go to the data fit program in the simbiology app, at the part when all the other variables are defined (image 2), there is no option to define this AHL row as a covariate that needs to be linked to a parameter of the simbiology model (this, as shown in the image can be done for the group, independent and dependent type of variables). Is there a way I can do to define the AHL parameter so that it changes between data groups in fit data program of the simbiology app?

Can we use more than one more model to fit the data. Whether fit data task in Simbiology allows it ?

I estimated 8 parameters of my glucose-insulin kinetics model(modified model of 'insulindemo.sbproj') using glucose concentration data as response and glucose, insulin doses as input dose data. The estimation was done by 'Fit Data' task of SimBiology. However, there was warning with details; *"Simulation with phi = [222.249598314537 144.778388565053 2.3665676931561 0.00609950427451014 0.156172487611996 0.0142886095746218 0.00444912107474936 1.27397631652191] could not be completed because: Integration Tolerance Not Met. Empty results have been returned for this simulation."* I used 'ode15s(stiff/NDF) solver with RelativeTolerance value of 1.0E-6. and estimation method was 'ga(Constrained optimization using genetic algorithm)' with TerminationTolerance of 1.0E-10 and MaximumGeneration of 800. What is the meaning of this warning message? and how could I treat it? Thank you for your interest.