Analyze PK/PD and mechanistic systems biology models
The SimBiology Model Analyzer app lets you analyze models of dynamic systems such as metabolic networks, signaling pathways, quantitative systems pharmacology (QSP), and pharamacokinetic/pharmacodynamic (PK/PD) of drugs. It provides several analysis methods for your models and various plots to visualize the results.
Using the app, you can:
Simulate a model to see its dynamic behavior over time.
Explore biological variability by simulating alternate scenarios such as virtual patients.
Estimate model parameters using nonlinear regression and nonlinear mixed-effects methods.
Perform parameter scans and sensitivity analysis to investigate the influence of model parameters and initial conditions on model behavior.
Specify units and let the app automatically converts the matching physical quantities to one consistent unit system.
Explore various dosing regimens.
Perform noncompartmental analysis (NCA) to compute PK parameters of a drug from its PK data.
View analysis results in various plots.
The app lets you visualize the analysis results using various plots including:
Time course of model quantities
Overlay of estimated results on experimental data
Fit quality measure plots such as confidence intervals, residuals, residual distribution, actual-versus-predicted, and box plot
Scatter plot matrix
MATLAB® toolstrip: On the Apps tab, under Computational Biology, click the app icon.
MATLAB command prompt: Enter
simBiologyModelAnalyzer opens the SimBiology Model