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Feeds
Frage
how to handle the error 'Levenberg-Marquardt algorithm the Jacobian at BETA0 is ill-conditioned'?
Hi, I try to run the fit in Simbiology using 'mixed effects' modeling. The transformation is exp(theta1+eta1). The 'error model...
2 Tage vor | 1 Antwort | 0
1
AntwortFrage
Why are population estimated parameters values the same as individual estimated parameters values?
Hi, I good patients data. I did population fit 'mixed effect'. The fits for individual patients were very good but the populati...
6 Tage vor | 1 Antwort | 0
1
AntwortFrage
Investigating the effect of two covariates to an estimated parameter
Hi, I have data for different patients and I want to investigate the effect of two covariates to an estimated parameter while...
6 Tage vor | 1 Antwort | 0
1
AntwortFrage
changes the the simulated mass with changing the absolute and relative tolerance
Hi, The mass of the tissue under the effect of a drug goes to very small values, i.e. in the order 10^-12, which is unrealistic...
4 Monate vor | 1 Antwort | 0
1
AntwortFrage
species go to negative values
Hi I developed a model in Simbiology simulating the effect of a drug on a tissue mass. Sometime, I received a message that the...
5 Monate vor | 2 Antworten | 0
2
AntwortenFrage
different event functions for the same species
Hi, I developed a model in Simbiology in which Fw is a parameter as a function of mass. The mass varies with time. I wa...
5 Monate vor | 1 Antwort | 0
1
AntwortFrage
A variable is specified by more than one assignment rule
Hi, I have a species A_Total = a + b + c, where a, b and c are other species in the same compartment. I have to set a boundary...
6 Monate vor | 1 Antwort | 0
1
AntwortFrage
Lognormal distribution parameters mu and sigma
Hi, I want to generate a lognormal distribution for a set of data measurments using Simbiology model analyzer. I need to inser...
6 Monate vor | 2 Antworten | 0
2
AntwortenFrage
Extracting Histogram data for plot generation
Hi, I generated a sample of lognormal distribution using Simbiology analyzer. I want to extract the data of the samples' hist...
6 Monate vor | 2 Antworten | 0
2
AntwortenFrage
Dimensional analysis issue because of the function 'log' in the rule
Hi! When I run a simulation in my model developed in Simbiolog, I received the following warning message: "Unable to perform d...
6 Monate vor | 1 Antwort | 0
1
AntwortFrage
Sensitivity analysis in Simbiology
Hi, I want to perform sensitivity analysis for my Simbiology model. I have encountered the following error. Would you please ex...
9 Monate vor | 1 Antwort | 0
1
AntwortFrage
Change in simulation output with changing in the units of stop time
Hi, I defined units for all parameters in my Smbiology model and the model runs simulations. The unit of time for all paramet...
etwa ein Jahr vor | 1 Antwort | 0
1
AntwortFrage
Failure of dimensional analysis for a rule
Hi, I have a rule y=x^0.35. x has the dimension of mass. An error message showed up saying that the exponent must be an integer...
etwa ein Jahr vor | 2 Antworten | 0
2
AntwortenFrage
Dimension of the species
Hi, In my model in Simbiology, it has a species with dimension of (molecules/time) and connected with a release rate reaction. ...
etwa ein Jahr vor | 1 Antwort | 0
1
AntwortFrage
Adding erf(x) to a rule in Simbiology
Hello, I have a rule in my model Y(x) = x, for example, in Simbiology app. I want o add the erf(x) for Y(x) to run a simulati...
mehr als ein Jahr vor | 1 Antwort | 0
1
AntwortFrage
Simulation error in Simbiology
Hi, I checked the tumor growth model in the library of Simbiology. I noticed if I increase the drug concentration to very high ...
mehr als ein Jahr vor | 1 Antwort | 0
1
AntwortFrage
Error message regarding CVODES
Hi, While I was running a simulation in a model I developed in Simbiology, I recieved the following error: CVODES returned -...
mehr als ein Jahr vor | 0 Antworten | 0
0
AntwortenFrage
Unites of the transfer rates
Hi, The simulations of my model differ at different unites of transfer rates. For example, the following are plots for the same...
mehr als ein Jahr vor | 1 Antwort | 0
1
AntwortFrage
Adding equations as a function of time
Hi, Could you please help me in solving the following: I set a trigger event in Simbiology that when 'X' species exceeds a cer...
mehr als ein Jahr vor | 1 Antwort | 0
1
AntwortFrage
The fluctuation of the content of a species between negative and positive
The model I am developing in Simbiology includes a drug species in which large repeated amounts of doses are injected. It has no...
mehr als ein Jahr vor | 1 Antwort | 0
1
AntwortFrage
What does a dashed line in simbiology mean?
I found a reaction connecting between two species_1 and species_2 in a simbiology model. There is a dashed line connecting betwe...
mehr als ein Jahr vor | 2 Antworten | 0
2
AntwortenFrage
Adding and configuring events
In simbiology, there is an event trigger that configure events at a SPECIFIC TIME. In my model, the content of m species is numb...
mehr als ein Jahr vor | 1 Antwort | 0
1
AntwortFrage
How to assign a transfer rate which changes with time in Simbiology?
I need to connect between two species in Simbiology. The transfer rate (k) in the reaction is an equation which depends on time ...
mehr als ein Jahr vor | 1 Antwort | 0