ADC Krogh Cylinder Model

A mechanistic model describing PK and intratumor distribution of a generalized ADC

The SimBiology model file described in the following manuscript:

Weddell, J., Chiney, M.S., Bhatnagar, S., Gibbs, J.P. and Shebley, M. (2020), Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology. Clin Transl Sci. (https://doi.org/10.1111/cts.12892)

Briefly: this model provides a minimal PBPK linked to a Krogh cylinder model to capture PK and intratumor distribution of a generalized ADC in metastatic breast cancer. The Krogh cylinder describes 14 spatial points across the tumor. Within each spatial point, the ADC binds surface antigen and is internalized, resulting in tumor cell death. A Simeoni tumor growth inhibition submodule is defined at each spatial point to model heterogeneous tumor cell growth and death spatially across the tumor.