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How to perform sequential fitting in Simbiology

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悦 吴
悦 吴 on 31 May 2021
Answered: Jeremy Huard on 1 Jun 2021
When fitting PKPD data, I would like to fit PK data first and freeze the PK parameters when fitting PD data. I wonder if there is a simple way to freeze parameter and do sequential fitting.
Thanks!
Yue

Accepted Answer

Jeremy Huard
Jeremy Huard on 1 Jun 2021
Hi 悦 吴,
you can indeed do this with the following steps:
1. fit PK data with a Fit program
2. right-click on the program results in the Model Analyzer Browser and choose Create Variant from estimated Parameter Values
3. then create a new fit program to fit the PD data and apply the variant created in step 2.
Best regards,
Jérémy

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