How to return multiple values by colfilt?

A matrix A 1000x1000, needd to be subdivided into patches of 5x5 (let us called B). then B is processed by subdividing it into 5 arrays of size 3x3 (let us called C). Finaly, the center point of each suarray (C1....C5) is replaced by the mean of each surrounfing elements.

C1=B(2:4,2:4);

C2=B(1:3,1:3);

C3=B(1:3,3:5);

C4=B(3:5,1:3);

C5=B(3:5,3:5);

These multiple changes need to returned as processing results (in our example 5 center values are changed at the same time). can we use colfilt with distinict option.