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In Simbiology, is the parameter estimates reliable, if I get the error " Iteration limit exceeded in the Laplacian algorithm. Returning result of the final iteration"

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I use the nlme model with exponential error and FOCE method of likelihood estimation to fit the PK data. I got the highest loglikeihood with this setting. But I also got a error/warning that
"Iteration limit exceeded in the Laplacian algorithm. Returning result of the final iteration"
What should I do to overcome this error. Should I even try to overcome this.? With this error, if I try to report the parameter estimate is it authentic.?
I am also attaching the algorithm settings of iteration with this question for reference regarding my settings.

Akzeptierte Antwort

Star Strider
Star Strider am 17 Jun. 2019
For that function, you can use the options created by the statset function to increase the number of iterations MaxIter beyond the default value of 200.
Try this:
opts = statset('nlmefit', 'MaxIter',1000);
to increase the iteration limit to 1000. (Assuming you are using the nlmefit function.)
NOTE — I have not tested this myself. It should work.
  6 Kommentare
Jeremy Huard
Jeremy Huard am 17 Jun. 2019
Dear Praveen,
please avoid creating a new thread for consecutive questions coming from the same issue. I see that you already posted this one in another thread and that it resulted from trying the suggestion provided in this other thread.
Keeping successive questions in the same thread will help us understand the context and keep the original question in mind.

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