Simulate model program predictions are different from fitted curve
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Bhargavi Srija Ramisetty
am 4 Mär. 2024
Kommentiert: Bhargavi Srija Ramisetty
am 11 Apr. 2024
Hi,
I built a PBPK model and fitted a few parameters to the model by using observed data. Next I created a variant of the fitted parameters and simulated the model with the variant values. Based on my previous experience, I expect to see same predcition profile as then fitted plot when using the same model, but the predcitions from "Simulate Model" program are different.
On the other hand when I add sensitivity calculation in the "Simulate model" program, then the predicted curve obtained matches with the fitted curve. I am not sure of this behavior of the model in Simbiology.
May I get some help on figuring out this issue?
Thank you in advance
4 Kommentare
Rick Paxson
am 5 Mär. 2024
Bearbeitet: Rick Paxson
am 5 Mär. 2024
Hi - so, can you confirm that you did the parameter estimation using one of those methods? And if so, did you set AbsoluteToleranceScaling to false for the fitting and then also for the simulation?
if so then I need to think more about this. In that case can you share the data and the project you are using?
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