Administer simultaneously different doses to different compartment in Simbiology

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Is it possible to administer two different dose objects (each one one to a different compartment) simultaneously using sbiosimulate in Simbiology? Or do I need to create a simulation scenario combining them. If so, could you share some code?
Thanks a lot!
Zinnia

Accepted Answer

Jeremy Huard
Jeremy Huard on 3 Nov 2021
Hi Zinnia,
yes, you can administer different doses with different targets at the same time during a simulation. You can do this with sbiosimulate or a SimFunction.
Here is an example with sbiosimulate:
% Create a two compartment model
pkm = PKModelDesign;
pkc= addCompartment(pkm, 'Central', 'DosingType', 'Bolus', ...
'EliminationType', 'linear-clearance', ...
'HasResponseVariable', true);
pkp = addCompartment(pkm, 'Peripheral', 'DosingType', 'Bolus', ...
'EliminationType', 'linear-clearance');
modelObj = pkm.construct;
% Create dose
dC = adddose(modelObj,'DoseC');
dC.Amount = 10;
dC.TargetName = 'Central.Drug_Central';
dP = adddose(modelObj,'DoseP');
dP.Amount = 20;
dP.TargetName = 'Peripheral.Drug_Peripheral';
dP.Interval = 5;
dP.RepeatCount = 1;
% Run Simulation
results = sbiosimulate(modelObj,[dC,dP]);
% Plot result
sbioplot(results);
set(gca, 'XLimitMethod','padded','YLimitMethod','padded');
grid on;
I hope it helps.
Best regards,
Jérémy
  1 Comment
Zinnia Parra-Guillen
Zinnia Parra-Guillen on 4 Nov 2021
Thanks a lot Jérémy! I was wrongly including the dose objects between quotes in the sbiosimulate function, that was the problem.
Best,
Zinnia

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