how to incorpolate various variables in simbiology model

hi, i'm creating the PBPK model which consists of 10 tissues with simbiology GUI

now, i would like to feed drug distribution parameter for each tissues in short time.

my understanding is that such variables should be incorpolated manually one by one as long as using simbiology GUI

is there any way to feed various parameters into simbiology model?

I think that it's the most ideal to export simbiology model to MATLAB code and implement some syntax to feed such variables

Thanks!

[Fulden Buyukozturk]

Hi Kazutaka,

You can export SimBiology model from GUI to MATLAB workspace and then use a script to add parameters. If you keep the GUI and the project file open, the changes you make through command-line will be reflected in the project in GUI as well.

To export, chose export model to workspace:

Documentation on how to add parameters and programmatic model building in general, please see:

https://www.mathworks.com/help/simbio/ref/addparameter.html

https://www.mathworks.com/help/simbio/gs/-model-a-gene-regulation-pathway.html

Let me know if this helps.

Fulden

[Fulden Buyukozturk]

Additionally, if you have multiple parameter values, let's say for different species (human, mouse, etc.), you can store those in model Variants and apply to the model during simulation:

https://www.mathworks.com/help/simbio/ug/variant-object.html

[Kazutaka Sekiguchi]

thank you so much and sorry for late reply

i understand how to export simbiology model to matlab code and feed parameters! I'll try that

[Fulden Buyukozturk]

Glad to hear. I'll put the "comment" above to the "answer field" below.

Answer 1

[Fulden Buyukozturk]

Hi Kazutaka,

You can export SimBiology model from GUI to MATLAB workspace and then use a script to add parameters. If you keep the GUI and the project file open, the changes you make through command-line will be reflected in the project in GUI as well.

To export, chose export model to workspace:

For documentation on how to add parameters and programmatic model building in general, please see:

https://www.mathworks.com/help/simbio/ref/addparameter.html

https://www.mathworks.com/help/simbio/gs/-model-a-gene-regulation-pathway.html

Additionally, if you have multiple parameter values, let's say for different species (human, mouse, etc.), you can store those in model Variants and apply to the model during simulation:

https://www.mathworks.com/help/simbio/ug/variant-object.html

Let me know if this helps.

Fuldend