Add multiple doses in ODEsolver

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Minu Pilvankar
Minu Pilvankar am 23 Sep. 2019
Beantwortet: Arthur Goldsipe am 24 Sep. 2019
I am trying to simulate multiple doses in a two compartment model. i have these odes for change in amount in each compartment.
d_amt_dt(1)= -(k12.*amt(1)) -(k10.*amt(1))+ (k21.*amt(2));
d_amt_dt(2) = (k12.*amt(1)) -(k21.*amt(2));
d_amt_dt = d_amt_dt';
For a single dose, I just change the initial condition amt1_0 = amount of dose given and get the expected output. However, how do I simulate multiple doses, e.g. every hour?
I can do this in Simbiology but I was wondering if there is a way to write code for that?

Akzeptierte Antwort

Arthur Goldsipe
Arthur Goldsipe am 24 Sep. 2019
Because doses introduce discontinuities in the solution, you basically need to stop the ODE simulation every time a dose is applied, update the appropriate states for the dose, and call the ODE solver with the updated initial conditions. This is what SimBiology does behind the scenes for you.

Weitere Antworten (1)

darova
darova am 23 Sep. 2019
There is way - ode45
To run your code every 1 hour look HERE

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