keeping a shared parameter across data sets when estimating parameters

2 Ansichten (letzte 30 Tage)
SP
SP am 21 Apr. 2018
I am trying to fit data to a non linear ODE system in order to estimate model parameters. I have data for three separate subjects as data1,data2,data3 measured over the same time span. In estimating these parameters I want to keep one of the estimated parameters to be common among all subjects.
I have written the code similar to the one at 'anlaysis.m' in here .
But, still I am getting a different value for the parameter that I want to keep constant.
My code is something like:
%Y has 4 columns. First column is time. Second column is data on
%first subject (data1), third colum is data on second subject (data2)
%third column is data on third subject (data3)
[fit,fval]=fmincon(@(parameters)ssq(parameters,Y),initial,[],[],[],[],lb,ub,[])
function SSE=ssq(parameters,Y)
time=Y(:,1);
SSE=0;
for i=1:3
fitted=model(parameters,time,i);
error1=fitted(:,1)-Y(:,i+1);
SSE1=sum(error1.^2);
SSE=SSE+SSE1;
end
end
function output= model(parameters,t,subject)
t=t(1:9)';
x0=[10^5,0.01];
a_1=parameters(1);%dependent on subject
a_2=parameters(2);%dependent on subject
a_3=parameters(3);%dependent on subject
r1=parameters(4);%common to all subjects
if subject==1
parameters1=[a_1,r1];
[time,pred1] = ode45(@(t,y)Equations(t,y,parameters1),t,x0,options);
output=pred1;
end
if subject==2
parameters2=[a_2,r1];
[time,pred2] = ode45(@(t,y)Equations(t,y,parameters2),t,x0,options);
output=pred2;
end
if subject==3
parameters3=[a_3,r1];
[time,pred3] = ode45(@(t,y)Equations(t,y,parameters3),t,x0,options);
output=pred3;
end
function s=Equations(t,y,eval)
s=zeros(2,1);
% b, k are know constant parameter values. The parameter estimated as
% eval(2) should be constant among all subjects
s(1)=(eval(2)*y(1))-eval(1)*y(2)*y(1);
s(2)=b*(k-y(2))*y(1)-eval(1)*y(2);
end
end
Can someone please explain to me how I can correct the code to evaluate a common parameter as I don't know if it works because it has been running for a very long time? Here, although at the moment I have written it to 3 subjects I actually ahve 10 subjects. So, I need to find an efficient way to deal with this.

Antworten (0)

Kategorien

Mehr zu Least Squares finden Sie in Help Center und File Exchange

Community Treasure Hunt

Find the treasures in MATLAB Central and discover how the community can help you!

Start Hunting!

Translated by